IIT Indore
Publications



    2023
  • Design, synthesis, and biological evaluation of novel thiourea derivatives as small molecule inhibitors for prostate-specific membrane antigen, Sengupta, S., Pandit, A., Krishnan, M. A., Sharma, R., Kularatne, S. K., Low, P. S., Venkatesh, C., Bioorganic Chem., 0, 00, (2023).
  • LIMK2-UBE2C Synergy drives castration-resistant prostate cancer, Shah, K., Lotana, H., Kumar, D., Bray, E., Krishnan, M. A., Venkatesh, C., BMC Biology, 0, 00, (2023).

    2022
  • In vitro and in vivo evaluation of targeted fluorescent imaging agents for diagnosis and resection of cancer, Yadav, K., Krishnan, M.A., Venkatesh, C., Curr. Protoc. Chem. Biol. 2(12), e623 (2022).
  • Optimizing affinity to prostate-specific membrane antigen by spacer modifications in a tumor spheroid model, Krishnan, M.A., Pandit, A., Sharma, R., Venkatesh, C., J. Biomol. Struct. Dyn., 40, 9909-9930, (2022).

    2021
  • Agarose micro-well platform for rapid generation of homogenous 3D tumor spheroids, Krishnan, M.A., Yadav, K., Venkatesh, C., Curr. Protoc. Chem. Biol. 1(7), e199, (2021).
  • Synthesis of 1-indolyl-3,5,8-substituted g-Carbolines: One-pot solvent-free protocol and biological evaluation, Dudhe, P., Krishnan, M.A., Yadav, K., Roy, D., Venkatasubbaih, K., Pathak, B., Venkatesh, C., Beilstein J. Org. Chem., 17, 1453-1463, (2021).
  • Folate-targeted verrucarin A reduces the number of activated macrophages in a mouse model of acute peritonitis, Venkatesh, C., Doorneweerd, D.D., Xia, W., Putt, K.S., Low, P.S., Bioorg. Med. Chem. Lett., 42, 128091, (2021).
  • Developing MicroSpherePlatform using a commercial hairbrush: An agarose 3D culture platform for deep-tissue imaging of prostate cancer, Krishnan, M.A., Venkatesh, C., ACS Appl. Bio. Mater. 5, 4254-4270, (2021).
  • Targeted QDot nanoprobe for early detection and surgical guidance of prostate cancer, Krishnan, M.A., Yadav, K., Roach, P., Venkatesh, C., Biomater. Sci. 9, 2295-2312, (2021).
  • Evaluation of the reducing potential of PSMA-containing endosomes by FRET imaging, Venkatesh, C., Shen, J., Putt, K.S., Low, P.S., Cancer Drug Resist., 4, 223-232, (2021).

    2020
  • Serendipitous base catalysed condensation-heteroannulation of iminoesters: A regioselective route to synthesis of 4,6-disubstituted 5-azaindoles, Dudhe, P., Venkatasubbaih, K., Pathak, B., Chelvam, V., Org. Biomol. Chem., 18, 1582-1587, (2020).
  • Synthesis of tubuvaline (Tuv) fragment of tubulysin via asymmetric dihydroxylation of homoallylamine, Reddy B. R., Vijay M, Krishnan M.A., Venkatesh, C., Synth. Commun., 51, 797-809, (2020).
  • Structure activity relationships (SAR) study to design and synthesize new tubulin inhibitors with enhanced anti-tubulin activity: In silico and in vitro analysis, Pandit, A., Yadav, K., Reddy, R.B., Sengupta, S., Sharma, R., Chelvam, V., J. Mol. Struct., 1223, 129204-129216 (2020).
  • Role of oxygen defects in basicity of Se doped ZnO nanocatalyst for enhanced triglyceride transesterification in biodiesel production, Krishna Rao, A.V.R., Dudhe, P., Venkatesh, C., Catal. Commun., 49, 106258, (2020).
  • Defects Induced multicolor down- and up-conversion fluorescence in Se doped ZnO nanorods by single wavelength excitation, Krishna Rao, A.V.R., Venkatesh, C., Opt. Mater., 107, 110122, (2020).

    2019
  • Tyrosine-based asymmetric urea ligand for prostate carcinoma: Tuning biological efficacy through in silico studies, Sengupta, S., Krishnan, M. A., Pandit, Amit, Dudhe, P., Sharma, R., Venkatesh C., Bioorganic Chem., 91, 103154-103167, (2019).
  • Synthesis of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and its lipophilic analogues for enhanced permeability in cancer cell lines, Reddy, B. R., Dudhe, P., Venkatesh, C., Synlett, 30, 77-81, (2019).
  • Comparison of prostate specific membrane antigen ligands in clinical translation research for diagnosis of prostate cancer, Sengupta, S., Krishnan, M. A., Chattopadhyay, S., Venkatesh, C., Cancer Reports., 2(4), e1169, (2019).

    2018
  • Synthesis of tubuphenylalanine and epi-tubuphenylalanine via regioselective hydroboration-oxidation of 1,1-substituted amino alkenes, Reddy, B. R., Dudhe, P., Chauhan, P., Sengupta, S., Venkatesh, C., Tetrahedron, 7, 6946-6953, (2018).
  • Efficient "turn-on" nanosensor by dual emission-quenching mechanism of functionalized Se doped ZnO nanorods for mercury (II)detection, Rao, A. V. R. K.,Reddy, B. R., Sengupta, S., Venkatesh, C., Applied Nanoscience, 8, 1973-1987, (2018).
  • Novel solid phase strategy for synthesis of ligand targeted fluorescent labelled chelating peptide conjugates as a theranostic tool for cancer, Sengupta, S., Krishnan, M. A., Dudhe, P., Reddy, R. B., Giri, B., Chattopadhyay, S., Venkatesh, C. Beil. J. Org. Chem., 14, 2665-2679, (2018).
  • Preparation of ligand targeted drug conjugates for cancer therapy and their evaluation in vitro, Krishnan, M. A., Sengupta, S., Venkatesh, C. Curr. Protoc. Chem. Biol. 000, (2018) (doi: 10.1002/cpch.50).
  • In vivo evaluation of ligand targeted drug conjugates for cancer therapy, Krishnan, M. A., Pandit, A., Venkatesh, C. Curr. Protoc. Chem. Biol. 000, (2018) (doi: 10.1002/cpch.49).
  • First report on 3D-QSAR and molecular dynamics based docking studies of GCPII inhibitors for targeted drug delivery applications, Pandit, A., Sengupta, S., Krishnan, M. A., Reddy, R. B., Sharma, R., Venkatesh, C., J. Mol. Struct., 1159, 179-192, (2018).
  • New mechanism for release of endosomal contents: Osmotic lysis via nigericin-mediated K+/H+ exchange, Rangasamy, L., Venkatesh C., Kanduluru, A. K., Srinivasarao, M., Bandara, N. A., You, F., Orellana, E. A., Kasinski, A. L., Low, P. S. Bioconjugate Chem., 29, 1047-1059, (2018).
  • Selective liposome targeting of folate receptor positive immune cells in inflammatory diseases, Poh, S., Venkatesh, C., Ayala-Lopez, W., Putt, K. S., Low, P. S., Nanomedicine:Nanotechnology, Biology, and Medicine, 14, 1033-1043, (2018).

    2017
  • Folate-conjugated liposomes target and deliver therapeutics to immune cells in a rat model of rheumatoid arthritis, Poh, S., Venkatesh, C., Lindsay, K., Ayala-Lopez, W., Balasubramanian, V., Putt, K. S., Low, P. S., Nanomedicine(Lond.), 12, 2441-2451, (2017).

    2016
  • Synthesis and Evaluation of Folate-Conjugated Phenanthraquinones for Tumor-Targeted Oxidative Chemotherapy, Kumar, A., Chelvam, V., Sakkarapalayam, M., Li, G., Pinero, N. S., Low, P. S., Alegria, A. E., O. J. Med. Chem. 6, 1-17 (2016).

    2015
  • Comparison of nanoparticle penetration into solid tumors and sites of inflammation: studies using targeted and nontargeted liposomes, Poh, S., Venkatesh, C., Low, P. S. Nanomedicine, 10, 1439, (2015).
  • Dupa conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selective prostate cancer cell targeting, Roy, J., Nguygen, T. X., Kandaluru, A. K., Venkatesh, C., Lv, W., Reddy, P.V.N., Low, P. S., Cushman, M., J. Med. Chem., 58, 3094 (2015).

    2014
  • In vivo mouse fluorescence imaging for targeted delivery kinetics, Tsai, E. H. R., Bentz, B. Z., Venkatesh, C., Gaind, V., Webb, K. J., Low, P. S., Optical Imaging 5, 2662-2678, (2014).

    2013
  • In vivo optical imaging of kinetics in a small animal for folate-targeted drug development, Tsai, H.-R., Bentz, B. Z., Venkatesh, C., Gaind, V., Webb, K. J., Low, P. S., Opt. Life Sci., (2013).
  • Small animal optical diffusion tomography with targeted fluorescence, Gaind, V., Tsai, H.-R., Webb, K. J., Venkatesh, C., Low, P. S., J. Opt. Soc. Am. A. 30, 1146, (2013).
  • Development of tumor-targeted near infrared probes for fluorescence guided surgery, Lindsay, K., Venkatesh, C., Charity, W., Mahalingam, S., Scott, P., Sumith, K., Low, P. S, Bioconjug. Chem., 24, 1075, (2013).
  • Use of folate-conjugated imaging agents to target alternatively activated macrophages in a murine model of asthma, Shen, J., Venkatesh, C., Cresswell, G., Low, P. S., Mol. Pharm., 10, 1918, (2013).

    • Publications from Postdoc and PhD
  • A folate receptor alpha-specific ligand that targets cancer tissue and not sites of inflammation. V. Balasubramanian, C. Venkatesh, S. A. Kularatne, S. Poh, W. Ayala-Lopez, P.S. Low. J. Nucl. Med. 53, 112, (2012).
  • LIMK2, A critical regulator effector of aurora A kinase-mediated malignancy. E. O. Jonhson, K-H. Chang, S. Ghosh, C. Venkatesh, K. Giger, P. S. Low, K. Shah. J. Cell Sci. 125, 1204, (2012).
  • Regioselective rapid analog synthesis of 1,3-(or 1,5-)diphenyl-4-aryl/heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki cross-coupling. T. A. Khan, S. Kumar, C. Venkatesh, H. Ila. Tetrahedron 67, 2961 (2011).
  • Synthesis and biological analysis of prostate-specific membrane antigen (PSMA)-targeted anti-cancer prodrugs. S. A. Kularatne, C. Venkatesh, H-K. Santhapuram, K.Wang, V. Balasubramanian, W. A. Henne, P. S. Low. J. Med. Chem. 53, 7767, (2010).
  • Model Studies for the Synthesis of Heliquinomycin-Preparation of New Spiroketals. C. Venkatesh, H.-U. Reissig, Synthesis 3605 (2008).
  • Dipolar Cycloaddition of Ethyl Isocyanoacetate to 3-Chloro-2-(methylthio)/2-(methylsulfonyl)quinoxalines: Highly Regio- and Chemoselective Synthesis of Substituted Imidazo[1,5-a]quinoxaline-3-carboxylates. G. S. M. Sundaram, B. Singh, C. Venkatesh, H. Ila, H. Junjappa, J. Org. Chem. 72, 5020, (2007).
  • 1-(Methyldithiocarbonyl)imidazole as Thiocarbonyl Transfer Reagent: A Facile One-pot Three-Component Synthesis of 3,5- and 1,3,5-Substituted 2-Thiohydantoins. G. S. M. Sundaram, C. Venkatesh, H. Ila and H. Junjappa Synlett, 251, (2007).
  • Highly Diastereoselective [3+2] Cycloaddition of Indoles with 2-Arylcyclopropyl Ketones and Diesters. C. Venkatesh, Prabal P. Singh, H. Ila and H. Junjappa Eur. J. Org. Chem. 5378, (2006).
  • Palladium Catalyzed Intramolecular N-Arylation of Heteroarenes: A Novel and Efficient Route to Benzimidazo[1,2-a]quinolines. C. Venkatesh, G. S.M. Sundaram, H. Ila, and H. Junjappa, J. Org. Chem. 71, 1280, (2006).
  • Heteroannulation of Nitroketene N,S-arylaminoacetals with POCl3: A Novel Highly Regioselective Synthesis of Unsymmetrical 2,3-Substituted Quinoxalines. C. Venkatesh, B. Singh, P. K. Mahata, H. Ila, H. Junjappa, Org. Lett. 7, 2169, (2005).
  • Studies on 2-[Bis(methylthio)methylene] acenaphthen-1-one: Efficient Routes to Acenaphthylene Fused Polycyclic Arenes/Heteroarenes and Heterocyclic Fluoranthene Analogs. Kausik Panda, C. Venkatesh, H. Ila, H. Junjappa. Eur. J. Org. Chem. 2045, (2005).
  • Heteroaromatic Annulation Studies on 2-[Bis(methylthio)methylene]-1-methyl-3-oxoindole: Synthesis of Novel Heterocyclo[b]fused Indoles. U. K. Syam Kumar, A. K. Yadav, C. Venkatesh, H. Ila, H. Junjappa Arkivoc, (viii), 20-27, (2004).
  • A Concise Formal Synthesis of Alkaloid Cryptotackiene and Substituted 6H-Indolo[2,3-b]quinolines. G. S. M. Sundaram, C. Venkatesh, U. K. Syam Kumar, H. Ila, H. Junjappa J. Org. Chem. 69, 5760 (2004).
  • Reaction of a-Oxoketene-N,S-arylamino acetals with Vilsmeier Reagents : An Efficient Route to Highly Functionalized Quinolines and Their Benzo/Hetero- Fused Analogues. P. K. Mahata, C. Venkatesh, U. K. Syam Kumar, H. Ila, H. Junjappa J. Org. Chem. 68, 3966-3975 (2003).
  • Domino Carbocationic Rearrangement of Aryl-2-(1-N-methyl/benzyl-3-indolyl)cyclopropyl Ketones: A Serendipitous Route to 1H-Cyclopenta[c]carbazole Framework. C. Venkatesh, H. Ila, H. Junjappa J. Org. Chem. 67, 9477 (2002).

Patents

  • Method of treating and diagnosing prostate cancer using PSMA targeting, Low, Philip Stewart; Venkatesh, Chelvam; Kim, Youngsoon. Feb., 2011, USA, PCT/US2011/026238.
  • Folate receptor alpha targeting ligands, Low, Philip Stewart; Balasubramanian, Vaitilingam; Venkatesh, Chelvam. Dec., 2010, US Provisional Application Serial No.61/428,842.
  • Endosomal escape of biologics (siRNA, peptide, aptamer, protein, gene, etc.) using ionophores in pathological cells. Low, Philip Stewart; Venkatesh, Chelvam. May, 2016, USA, PCT/US2016/031738.
  • New small molecule inhibitors/ligands for early diagnosis and therapy of prostate specific membrane antigen (PSMA+) cancers and neurodegenerative diseases, Venkatesh, Chelvam, Sengupta, S., Krishnan, M. A., Pandit, A. Nov. 2018, Indian patent, Application no. 201821044594.
  • Method and system for metal-free solvent-free synthesis of fused-pyrido heterocycles and their biological activities against cancer and multi-drug resistant pathogens, Venkatesh, C., Dudhe, P., Krishnan, M. A., Sonawane, A., July 2019, Indian Patent, Application no. 201921029311.
  • New small molecule inhibitors/ligands for early diagnosis and therapy of prostate specific membrane antigen (PSMA+) cancers and neurodegenerative diseases, Venkatesh, C., Sengupta, S., Krishnan, M. A., Pandit, A. Nov. 2019, USA patent, Application no. 16695851.
  • Third generation tubulysin analogues and process of preparation thereof, Chelvam V., Pandit A., Reddy R.B., Yadav K., Pathak B., Roy, D. 2020, Indian Patent, Application No.202021036140.
  • Metal-free solvent-free synthesis of fused-pyrido heterocycles and biomedical applications. Venkatesh C., Dudhe P., Krishnan M. A., Sonawane, A. 2020, USA patent, Application no. 16931838.
  • Third generation tubulysin analogues and process of preparation thereof, Chelvam V., Pandit A., Reddy R.B., Yadav K., Pathak B., Roy, D. 2021, USA Patent, Application No.17/198,918.
Dr. Venkatesh Chelvam
Professor
Chemistry

cvenkat[at]iiti.ac.in